If the problem is originated from woman and her eggs are not in good quality and
quantity in the couples that can't have baby, oocyte donation (egg donation ) is used for
getting pregnancy. The general success rate is more than 80% in IVF cycles with
egg donation. So every woman can get her baby in every age.
To whom egg donation is performed?
-to women who have uterus but undergoing pre-menopause
-to women who undergoing menopause
-to women that their ovaries are taken out for any reason
-to women whose ovaries lost their activity because taking radiotherapy or chemotherapy
-to women whose eggs are low in quantity and quality
-to women who have recurrent miscarriages
-to women who have genetic disorders that can be inherited to their babies...
How to use egg donor for egg donation?
After deciding that egg donation is necessary for the patient couple, the donor is selected from the donor list of the center that consists of the women who applied for sharing their eggs. While selecting the suitable donor it is necessary to be careful about physical properties of the couple.
After selecting the donor, menstrual periods of both donor and mother candidate is programmed to be gone together. And the eggs are induced in donor, while uterus is prepared in mother candidate and after collecting eggs from donor and fertilized with father candidates sperms the embryos are transferred on day 3 or 5 of their growing. And couple starts for waiting pregnancy test on 12. day after transfer.
The Requirements for Egg Donors:
1- the age of egg donor must be 20-35
2- donor must be physically healthy
3- the body mass index must be 19-29
4- donor must be psychologically healthy
5- donor shouldn't have drug dependent
6-donor shouldn't have any inherited genetic disorder
7-donors ovaries both should be healthy
8-should have karyotype analysis result 46, XX
9-required genetic and laboratory test are performed (Anti-Hiv 1, 2, HbsAg, Anti HBc, Anti-HCV, Syphilis, and sometimes if required HTLV-1 RhD, CMV, T.cruzi, cystic fibrosis, thalasemia, ...)
How Egg Donation is performed?
Egg donation consists of three stages;
1-Deciding that we have to use egg donation and making PRE-PREPARATION:
making required tests and getting reports for mother candidate (FSH, LH, Estradiol, Prolaktin on day 2 or 3 of menstrual bleeding, AMH on any day) and be sure that egg donation is needed. After this, starting to use some medicine to woman partner to refresh and strengthen the uterus and to man partner for inducing the quality of sperms. Donor is selected and bleeding time programing is performed for donor and mother candidate to start bleeding on same day. If the mother candidate is in menopause, bleeding is not required for her. (This stage takes 1 week - 1 month and can be performed in patients' country).
on day 2 or 3 of bleeding (menstrual cycle, for both donor and mother candidate) in the month that couple decide to come for the treatment, making required extra tests to both women and start using some more medication like injections for inducing eggs in donor and some medicine for mother candidate for preparing the uterus for embryo. Generally this medication stage takes 10 days. If the mother candidate is in menopause, bleeding is not required for her (this stage takes nearly ten days and can be performed in patients' country). After 12 days (on 14. day of bleeding) couple must be in Cyprus for oocyte pick up (OPU, egg collecting).
this starts with oocyte pick up (egg collection) from donor and ends with embryo transfer on day 3 or 5 of embryo development to the uterus of mother candidate. The eggs that are collected from donor woman are fertilized with the father candidate sperms on OPU Day (Day 0). After 3 or 5 days, embryos are transferred to the uterus of mother candidate. After transfer operation , couples can return to their countries whenever they want (this stage takes 3-5 days and patients must be in Cyprus). On 12. day after transfer beta-HCG test in blood must be done for learning pregnancy is negative or positive.